Manchester United interim boss Ole Gunnar Solksjaer says Anthony Martial and Jesse Lingard could be out for two to three weeks after coming off in the midweek defeat by Paris St-Germain.
Manchester City manager Pep Guardiola expects his players "to suffer" when they travel to League Two Newport County on Saturday for their FA Cup fifth-round tie.
Crystal Palace manager Roy Hodgson does not know if Wilfried Zaha will be available for their trip to Doncaster Rovers on Saturday as they await an appeal to the additional one-match ban he received for being sent off for improper conduct at Southampton.
With nine points between Tottenham and Manchester United in 3rd and 4th respectively, the top six can be divided into three teams challenging for the title, and three more hoping to nab the last Champions League qualification spot.
Who has the most favourable fixtures? Take a look below.
Manchester City
Remaining fixtures (current league position): West Ham (10),
Bournemouth (11),
Watford (8),
Man Utd (4),
Fulham (19),
Cardiff (17),
Crystal Palace (13),
Tottenham (3),
Burnley (15),
Leicester (12),
Brighton (14)
Average league position of remaining opponents: 11.5
Liverpool
Remaining fixtures (current league position): Man Utd (4),
Watford (8),
Everton (9),
Burnley (15),
Fulham (19),
Tottenham (3),
Southampton (18),
Chelsea (6),
Cardiff (17),
Huddersfield (20),
Newcastle (16),
Wolves (7)
Average league position of remaining opponents: 11.8
Tottenham
Remaining fixtures (current league position): Burnley (15),
Chelsea (6),
Arsenal (5),
Southampton (18),
Crystal Palace (13),
Liverpool (2),
Brighton (14),
Huddersfield (20),
Man City (1),
West Ham (10),
Bournemouth (11),
Everton (9)
Average league position of remaining opponents: 10.3
Manchester United
Remaining fixtures (current league position): Liverpool (2),
Crystal Palace (13),
Southampton (18),
Arsenal (5),
Man City (1),
Watford (8),
Wolves (7),
West Ham (10),
Everton (9),
Chelsea (6),
Huddersfield (20),
Cardiff (17)
Average league position of remaining opponents: 9.6
Chelsea
Remaining fixtures (current league position): Brighton (14),
Tottenham (3),
Fulham (19),
Wolves (7),
Everton (9),
Cardiff (17),
West Ham (10),
Liverpool (2),
Burnley (15),
Man Utd (4),
Watford (8),
Leicester (12)
Average league position of remaining opponents: 10
Arsenal
Remaining fixtures (current league position): Southampton (18),
Bournemouth (11),
Tottenham (3),
Man Utd (4),
Wolves (7),
Newcastle (16),
Everton (9),
Watford (8),
Crystal Palace (13),
Leicester (12),
Brighton (14),
Burnley (15)
Average league position of remaining opponents: 10.8